Lots of Yum, for starters. Use 2 or 3 different types of ground meat. Beef, pork, veal, turkey, or sausage. The fat in the meat adds flavor and moisture. When one of the meats is low-fat, you will want 25-30% fat in either of the other two meat types.
Seasonings: A package of onion soup mix is the SIS (simple is smart) secret ingredient for the best tasting, most flavorful meatloaf. It is a done for you mixture that is perfect with the meat. Any brand will make the meatloaf delicious.
Lastly, extra moisture with ketchup, eggs, and steak sauce and bread crumbs. How does dry bread crumbs add moisture? It lightens the texture of the loaf and absorbs and locks the moisture within the loaf.